To Inclusion and Integration

Let’s talk about 2 teachable Trump moments….

Gene linked to life-threatening respiratory viral infections

August 13, 2024 Imma Perfetto

https://cosmosmagazine.com/australia/gene-linked-to-life-threatening-respiratory-viral-infections/

Doctors may soon be able to predict whether your influenza infection will become life-threatening, or if you’ll recover quickly.

Scientists have identified a gene associated with whether patients hospitalised with respiratory viral infections experience mild disease or life-threatening complications.

According to the new study published in Cell, expression levels of the gene, OLAH, is critical in determining disease severity.

The University of Melbourne’s Dr Brendon Chua, a viral and translational immunologist at the Doherty Institute for Infection and Immunity and co-senior author of the paper, says: “Our first ‘aha’ moment occurred during our analysis of patients hospitalised with A(H7N9) [avian] influenza, where we discovered a consistent association between high expression levels of OLAH and fatal outcomes.

“Conversely, patients who recovered exhibited very low OLAH expression throughout their hospital stay.

Patients severely infected with seasonal influenza virus, SARS-CoV-2, respiratory syncytial virus (RSV) and children experiencing multisystem inflammatory syndrome, a rare but serious complication of COVID-19, also show elevated levels of OLAH expression.

A graphical abstract of the study showing that decreased olah expression results in mild disease and increased olah expression results in greater disease severity,
Credit: Jia XX, et al. High expression of oleoyl-ACP-hydrolase underpins life-threatening respiratory viral diseases. Cell (2024). DOI: https://doi.org/10.1016/j.cell.2024.07.026

The OLAH gene encodes an enzyme, oleoyl-acyl-carrier-protein hydrolase (OLAH), which mediates the production of a fatty acid. Higher expression of the gene results in higher levels of fatty acids, which exacerbates viral infections.

“Further investigation using animal models and cell cultures revealed that OLAH is pivotal in driving life-threatening inflammation associated with respiratory viruses,” says Chua.

“What’s interesting is that we all have this gene, but its expression varies during the early phases of a respiratory infection, which is why some of us recover faster while others experience severe complications.”

The research team is now working to develop OLAH-based diagnostic methods to screen hospitalised patients. They are also exploring how OLAH can inform the development of therapeutic treatments for viral pathogens.

The University of Melbourne’s Professor Katherine Kedzierska, head of the Human T cell Laboratory at the Doherty Institute and co-senior author of the paper, says: “We’re really excited about the potential of the OLAH gene to serve as a universal indicator of disease severity across different respiratory infections.

“Imagine if your doctor could predict whether your respiratory infection will become life-threatening or if you’ll recover quickly? Our findings suggest that OLAH expression levels could be used as a cutting-edge tool in assessing patients’ prognosis, empowering clinicians with crucial insights for early risk assessment and personalised treatment strategies.”

Egyptians of Old Could Have Used Hydraulic Lifts for Work

J.K. Rowling and Elon Musk Named in Cyberbullying Lawsuit Filed by Algerian Boxer Imane Khelif After Olympic Win (EXCLUSIVE)

By Elsa KeslassyAlex Ritman

(The arc bends toward justice, though slowly.)

https://variety.com/2024/tv/news/jk-rowling-elon-musk-imane-khelif-lawsuit-1236105185/

J.K. Rowling and Elon Musk have both been named in a criminal complaint filed to French authorities over alleged “acts of aggravated cyber harassment” against Algerian boxer and newl crowned Olympic champion Imane Khelif.

Nabil Boudi, the Paris-based attorney of Khelif, confirmed to Variety that both figures were mentioned in the body of the complaint, posted to the anti-online hatred center of the Paris public prosecutor’s office on Friday.

The lawsuit was filed against X, which under French law means that it was filed against unknown persons. That “ensure[s] that the ‘prosecution has all the latitude to be able to investigate against all people,” including those who may have written hateful messages under pseudonyms, said Boudi. The complaint nevertheless mentions famously controversial figures. (snip)

Boudi said that although the complaint mentions names, “What we’re asking is that the prosecution investigates not only these people but whoever it feels necessary. If the case goes to court, they will stand trial.”

Boudi also claimed that while the lawsuit was filed in France, “it could target personalities overseas,” pointing out that “the prosecutor’s office for combating online hate speech has the possibility to make requests for mutual legal assistance with other countries.” He added that there were agreements with the U.S. equivalent of the French office for combating online hate speech. (snip-More)

Kamala HQ understands the assignment

Found it here: Read on Substack

The Elon Musk ❤ Donald Trump “interview” on X was an embarrassing cringefest, as expected. by Political Humor

And what’s with Trump’s weird lisp? Is that why he’s not campaigning? Is Dementia Donnie having denture problems?

Read on Substack

AP News: An Israeli airstrike on a Gaza school kills at least 80 people, Palestinian health officials say

Well It happened again.

Hi all.  For two days I have worked on a couple posts.  Never seeming able to get to the end of them.  I get up at 2 or early and work on the Male Survivor site, then I have an hour or more long audio call with a fellow survivor, then I go to Joe My God to collect memes and see if there are stories I should post.  In between there is the morning walk with Ron, feeding and cleaning up after cats, and doing home stuff.  After showering I notice most of the morning is gone.  During The Majority Report which comes on at noon and runs for 2 or 3 hours, I turn the monitor around and put on headphones and do the dishes, a job that takes me about two hours.  Then another check in with the person I had the audio call with.  Then supper.  I realize the day went by without me being able to check my blog, without reading what Ali and Randy posted, not even time to reply to comments before I am struggling to stay awake and end up going to bed. That doesn’t include the days my pain or exhaustion doesn’t require me to go lay down.   Get up far too early only to do it all again.  

So last night before going to bed I put all the comments I could find in open tabs.  I am going to work on them now.  But I know some passed the last few days I did not see.  If you had something you wanted to say to me and I did not reply, please send it again even on a different thing I post.   Remember I do not see comments on Ali’s or Randy’s posts unless I go to the post page.  I do care about the blog, I do love the comments.  I am simply severely trying to do too much and deal with personal issues also.  I have to cut something and concentrate on what is important, which is Ron, the blog, and you all.  As I have taken to saying lately, far more than I ever thought I would, I care about you, I care for you.  Ron wants me to watch more movies and TV shows like Piccard, wants us to go out to eat, wants us to spend more time together.  All of these will eat into my online time.  I have some thinking to do, and right now thinking is sometimes hard for me.   Best wishes.  Hugs. Scottie

tRump’s and his supporters including the republican media arm Fake news Fox. And other weird republians stuff

Trump Spox: J.D. Vance Will Need To “Deep Clean” Air Force 2 To Get Rid Of The “Smell” From Kamala Harris

Bolton: Trump Doesn’t Even Know That He’s Lying

Jesse Watters: Walz Hugs His Wife In A “Weird” Way

MN Paper Debunks The Cult’s “Tampon Tim” Claims

Rather obviously, this is meant to lay the groundwork to contest the result of the November election. Maricopa County includes Phoenix.

The real cover:

“It’s different because while Joe Biden was incompetent by senility, Kamala Harris is incompetent by stupidity. She has supported 100% of Joe Biden’s disastrous policies. And that’s why our strategy will not change. Overall, we will continue to hammer away on the message that you just heard President Trump share for more than an hour at that press conference, taking questions on all types of issues and calling out Kamala Harris for her failure.” – Trump campaign spokesperson Karoline “Cow-Toe” Leavitt, this afternoon on Fox News.
On Tuesday, the same election board voted to allow local officials to refuse to certify election results. Fulton County includes Atlanta.
More Putinism on the march. Prominent US cultists are already hailing the move on X. Photo: Bulgarian PM Dimitar Glavchev. Bulgaria is a member of the EU and NATO.
Read the full article. Peters is accused, among other things, of giving a staffer’s security badge to a conspiracy theorist that she allowed to access county voting equipment. Her trial is now in its eighth day.
Elagabalus3 days ago
“The law…forbids teachers from raising gender identity and sexual orientation issues with younger students.”


Excuse me, but every time a straight teacher mentions his or her heterosexually-married husband, wife, or kids, the issue of sexual orientation gets raised, because as we all know, whenever straight people mention their spouse everyone immediately goes straight to thinking about the two of them having sex and that makes everyone else feel uncomfortable, and we can’t have that. Oh, wait…no, that’s only the way it works for gay people.


zhera  The goal is to shove kids so far into the closet they will never find their way out.

 Longtime JMG readers may recall Cleta Mitchell for her work with the anti-LGBTQ hate group NOM. In 2011, she caused infighting within the now-defunct homocon group GOProud when she spearheaded a movement to boycott CPAC over GOProud’s attendance. GOProud founder Chris Barron called her a “bigot,” prompting now-Fox News host Tammy Bruce to resign from the group. Barron then apologized. Of note, Mitchell appears to have a particular hatred for gay men because her first husband left her for another man. In 1992, Mitchell’s second husband was convicted on five felony counts of banking fraud.

Saving an Underwater World

Michael Goldberg and his team of volunteer divers are resurrecting reefs, one coral at a time.

Ken Budd https://www.saturdayeveningpost.com/2024/08/saving-and-underwater-world/

Thirty years ago, when Michael Goldberg would dive in the glimmering blue water of the British Virgin Islands, the reefs were teeming with life. “The expanse of these reefs was astounding,” says Goldberg, a cofounder of I.CARE, a Florida-based reef restoration organization. “The corals were so thick and lush.”

Today those reefs are dying. In much of the Atlantic Ocean, including the Florida Keys, where the 61-year-old Goldberg lives, roughly 70-95 percent of the coral is gone, devastated by disease, rising sea temperatures, and other existential threats.

By 2015, as the reefs declined, Goldberg faced a decision. He would either leave the scuba industry — since 2004, he has owned Key Dives, which provides diving and snorkeling on the Keys’ Islamorada reefs — or take action to restore the coral. Fortunately for Florida, the ocean, and humanity, he chose the latter.

In 2019, Goldberg cofounded I.CARE (Islamorada Conservation and Restoration Education). The mission: To restore and maintain Islamorada’s reefs by teaming with local businesses, residents, and visitors, including local dive shops and recreational divers. Activities range from underwater trash clean-ups — since 2021, divers have lugged 20,000 pounds of debris to the surface — to coral transplants. Over the past three years, I.CARE has planted over 15,000 corals on six different reefs.

The need is urgent. Coral reefs provide food and shelter to thousands of organisms — crustaceans, fish, anemones, sponges — and protect shorelines from storms and erosion. The reefs’ economic benefits include tourism and commercial and recreational fishing. Coral has even been used in medical technologies such as “bone grafting techniques and possible treatments for diseases including Alzheimer’s and cancer,” I.CARE notes.

“I love educating people about the importance of this, but the most gratifying thing for me is seeing the coral grow,” Goldberg says. “I love seeing little baby corals thrive in a harsher environment than I ever imagined, and knowing that despite all the challenges, we’re seeing success.”

Goldberg’s career initially focused on money management rather than ocean management. His love of the water began when he was a boy in Los Angeles, but his family moved to Chicago when he was 10, and he later studied finance at Northern Illinois University. On a summer trip to Acapulco, he dove for the first time, purely, he says, “as a lark.”

“Someone got me some gear, and I wasn’t certified, and I didn’t know what I was doing,” he says. Acapulco is not known for stellar diving experiences, but he loved it: “I was just so enamored with being underwater.”

After that, he was hooked. He earned his diving certification and then moved back to one of L.A.’s beach communities and became an instructor. Before long, he and his wife decided to move to the British Virgin Islands. Eight years later, the couple returned to the United States and opened Key Dives in Islamorada.

Hope and water: “If I wasn’t optimistic, I wouldn’t keep doing this,” says I.CARE cofounder Michael Goldberg. (Photo courtesy Michael Goldberg)

Goldberg has made over 10,000 dives, swimming not only with dolphins and schooling sharks, but within 15 feet of a humpback whale as it breached. And yet the vast coral reefs have always intrigued him most, whether diving alone or taking clients off the island of Virgin Gorda in the British Virgin Islands.

“There was this one unique piece of coral that I would swim underneath — it was like a tree,” he says. “Most people want to see fish, but to me, that coral was always the highlight of the dive.”

In 2017, Goldberg met Kylie Smith, who was working on her Ph.D. at Clemson University and studying coral in the Florida Keys. Smith would fill her tank at Key Dives, and Goldberg, who was “already shifting my business toward conservation,” would tap into her aquatic expertise.

“When I met Dr. Smith, I would pepper her with questions — she couldn’t walk in my store and leave in quick fashion,” Goldberg says. Their discussions eventually moved from the dive shop to a beer garden at The Florida Keys Brewing Company. “We would sit and chat, and I kept saying to her, I’ve got an idea to empower recreational divers so that they can become citizen scientists — not only because they want to be part of the solution, but because they need to be a part of the solution. That’s the largest potential boots-on-the-ground army that can enact so much of what we do.”

Those discussions led them to co-launch I.CARE. By January 2021, volunteer divers had transplanted I.CARE’s first corals.

For the coral restoration, divers use coral raised in nurseries. Once it’s planted on the reefs, the coral will, hopefully, reproduce into a coral colony — but the process is slow. It can take 20-50 years for coral to grow large enough to spawn.

To speed up reproduction, I.CARE uses a process called micro-fragmentation. Larger corals are cut into thumbnail-size pieces and grown in a nursery. When those pieces grow to about the size of a 50-cent piece, they are planted edge to edge on a living coral structure. After a few years, the coral fuse to become one larger coral, and they’ll start to spawn in about 7 to 10 years.

For the micro-fragmentation work, I.CARE rescues coral that has broken free from the main reef structure due to storms and substrate erosion.

“What is cool about these corals is that these are the survivors. They are the most resilient, the ones that have persisted despite all the disease and heat,” says Goldberg. “It’s survival of the fittest in the truest sense, and the ones we are using to rebuild our precious reefs.”

Despite the advances, the challenges are huge, both for I.CARE and the planet. During the intense heat of summer 2023, most of I.CARE’s seemingly healthy coral fragments died at one of Goldberg’s favorite reefs. “I cried underwater,” he admits. But he prefers to focus on the organization’s victories. Seventy-seven of the fragments survived and are thriving.

“If I wasn’t optimistic, I wouldn’t keep doing this,” he says. “We’ve had successes, and we can build on those successes.”

When it comes to restoring the reefs for future generations, he offers a simple vow: “We’re not gonna give up.”

Ken Budd has written for The Washington Post, The Atlantic, The New York Times, National Geographic Traveler, and many more. He is the author of an award-winning memoir, The Voluntourist.

This article is featured in the July/August 2024 issue of The Saturday Evening Post.