Gene linked to life-threatening respiratory viral infections

August 13, 2024 Imma Perfetto

https://cosmosmagazine.com/australia/gene-linked-to-life-threatening-respiratory-viral-infections/

Doctors may soon be able to predict whether your influenza infection will become life-threatening, or if you’ll recover quickly.

Scientists have identified a gene associated with whether patients hospitalised with respiratory viral infections experience mild disease or life-threatening complications.

According to the new study published in Cell, expression levels of the gene, OLAH, is critical in determining disease severity.

The University of Melbourne’s Dr Brendon Chua, a viral and translational immunologist at the Doherty Institute for Infection and Immunity and co-senior author of the paper, says: “Our first ‘aha’ moment occurred during our analysis of patients hospitalised with A(H7N9) [avian] influenza, where we discovered a consistent association between high expression levels of OLAH and fatal outcomes.

“Conversely, patients who recovered exhibited very low OLAH expression throughout their hospital stay.

Patients severely infected with seasonal influenza virus, SARS-CoV-2, respiratory syncytial virus (RSV) and children experiencing multisystem inflammatory syndrome, a rare but serious complication of COVID-19, also show elevated levels of OLAH expression.

A graphical abstract of the study showing that decreased olah expression results in mild disease and increased olah expression results in greater disease severity,
Credit: Jia XX, et al. High expression of oleoyl-ACP-hydrolase underpins life-threatening respiratory viral diseases. Cell (2024). DOI: https://doi.org/10.1016/j.cell.2024.07.026

The OLAH gene encodes an enzyme, oleoyl-acyl-carrier-protein hydrolase (OLAH), which mediates the production of a fatty acid. Higher expression of the gene results in higher levels of fatty acids, which exacerbates viral infections.

“Further investigation using animal models and cell cultures revealed that OLAH is pivotal in driving life-threatening inflammation associated with respiratory viruses,” says Chua.

“What’s interesting is that we all have this gene, but its expression varies during the early phases of a respiratory infection, which is why some of us recover faster while others experience severe complications.”

The research team is now working to develop OLAH-based diagnostic methods to screen hospitalised patients. They are also exploring how OLAH can inform the development of therapeutic treatments for viral pathogens.

The University of Melbourne’s Professor Katherine Kedzierska, head of the Human T cell Laboratory at the Doherty Institute and co-senior author of the paper, says: “We’re really excited about the potential of the OLAH gene to serve as a universal indicator of disease severity across different respiratory infections.

“Imagine if your doctor could predict whether your respiratory infection will become life-threatening or if you’ll recover quickly? Our findings suggest that OLAH expression levels could be used as a cutting-edge tool in assessing patients’ prognosis, empowering clinicians with crucial insights for early risk assessment and personalised treatment strategies.”

AP News: An Israeli airstrike on a Gaza school kills at least 80 people, Palestinian health officials say

Well It happened again.

Hi all.  For two days I have worked on a couple posts.  Never seeming able to get to the end of them.  I get up at 2 or early and work on the Male Survivor site, then I have an hour or more long audio call with a fellow survivor, then I go to Joe My God to collect memes and see if there are stories I should post.  In between there is the morning walk with Ron, feeding and cleaning up after cats, and doing home stuff.  After showering I notice most of the morning is gone.  During The Majority Report which comes on at noon and runs for 2 or 3 hours, I turn the monitor around and put on headphones and do the dishes, a job that takes me about two hours.  Then another check in with the person I had the audio call with.  Then supper.  I realize the day went by without me being able to check my blog, without reading what Ali and Randy posted, not even time to reply to comments before I am struggling to stay awake and end up going to bed. That doesn’t include the days my pain or exhaustion doesn’t require me to go lay down.   Get up far too early only to do it all again.  

So last night before going to bed I put all the comments I could find in open tabs.  I am going to work on them now.  But I know some passed the last few days I did not see.  If you had something you wanted to say to me and I did not reply, please send it again even on a different thing I post.   Remember I do not see comments on Ali’s or Randy’s posts unless I go to the post page.  I do care about the blog, I do love the comments.  I am simply severely trying to do too much and deal with personal issues also.  I have to cut something and concentrate on what is important, which is Ron, the blog, and you all.  As I have taken to saying lately, far more than I ever thought I would, I care about you, I care for you.  Ron wants me to watch more movies and TV shows like Piccard, wants us to go out to eat, wants us to spend more time together.  All of these will eat into my online time.  I have some thinking to do, and right now thinking is sometimes hard for me.   Best wishes.  Hugs. Scottie

tRump’s and his supporters including the republican media arm Fake news Fox. And other weird republians stuff

Trump Spox: J.D. Vance Will Need To “Deep Clean” Air Force 2 To Get Rid Of The “Smell” From Kamala Harris

Bolton: Trump Doesn’t Even Know That He’s Lying

Jesse Watters: Walz Hugs His Wife In A “Weird” Way

MN Paper Debunks The Cult’s “Tampon Tim” Claims

Rather obviously, this is meant to lay the groundwork to contest the result of the November election. Maricopa County includes Phoenix.

The real cover:

“It’s different because while Joe Biden was incompetent by senility, Kamala Harris is incompetent by stupidity. She has supported 100% of Joe Biden’s disastrous policies. And that’s why our strategy will not change. Overall, we will continue to hammer away on the message that you just heard President Trump share for more than an hour at that press conference, taking questions on all types of issues and calling out Kamala Harris for her failure.” – Trump campaign spokesperson Karoline “Cow-Toe” Leavitt, this afternoon on Fox News.
On Tuesday, the same election board voted to allow local officials to refuse to certify election results. Fulton County includes Atlanta.
More Putinism on the march. Prominent US cultists are already hailing the move on X. Photo: Bulgarian PM Dimitar Glavchev. Bulgaria is a member of the EU and NATO.
Read the full article. Peters is accused, among other things, of giving a staffer’s security badge to a conspiracy theorist that she allowed to access county voting equipment. Her trial is now in its eighth day.
Elagabalus3 days ago
“The law…forbids teachers from raising gender identity and sexual orientation issues with younger students.”


Excuse me, but every time a straight teacher mentions his or her heterosexually-married husband, wife, or kids, the issue of sexual orientation gets raised, because as we all know, whenever straight people mention their spouse everyone immediately goes straight to thinking about the two of them having sex and that makes everyone else feel uncomfortable, and we can’t have that. Oh, wait…no, that’s only the way it works for gay people.


zhera  The goal is to shove kids so far into the closet they will never find their way out.

 Longtime JMG readers may recall Cleta Mitchell for her work with the anti-LGBTQ hate group NOM. In 2011, she caused infighting within the now-defunct homocon group GOProud when she spearheaded a movement to boycott CPAC over GOProud’s attendance. GOProud founder Chris Barron called her a “bigot,” prompting now-Fox News host Tammy Bruce to resign from the group. Barron then apologized. Of note, Mitchell appears to have a particular hatred for gay men because her first husband left her for another man. In 1992, Mitchell’s second husband was convicted on five felony counts of banking fraud.

Let’s talk about Trump musing about Biden and the Constitution….

Media report on tRump’s age and infirmities as much as you did Biden’s, please

US Athletes Discover Joys Of Universal Healthcare In Olympic Village by Rebecca Schoenkopf

This is one of those feel-good stories that is actually very depressing when you think about it! Read on Substack

Snippets:

Wikimedia Commons

There’s a lot of money to be made on the Olympics — though not necessarily by the people participating in them (or most people who live in the host cities). Those athletes who participate don’t get paid (unless they get sponsorship deals) and, as a result, many of them go into poverty while trying to go for the gold. Training costs are huge and so, often, are the medical bills.

But not when they’re at the Olympic Village!

Ariana Ramsey, who won a bronze medal as part of the US female rugby team has been going viral on TikTok, talking about how amazing it’s been getting free healthcare at the Olympic Village — and in the days following her victory, she was able to celebrate by going to the gynecologist, dentist and an ophthalmologist, where she was able to get free glasses as well.

Via Sports Illustrated:

Ramsey came to Paris as a rugby player. She is leaving as a healthcare influencer. More than 135,000 people have watched her initial TikTok, and another of the half-dozen follow-up videos she has made has pulled in more than 570 views. That is fine with her. The more she thinks about it, the more frustrated she is that she’s so astonished by the concept. 

“That’s just America and their privatized healthcare system,” she laments in an interview, adding, “I’ll fight for universal healthcare.”

The idea has gone viral in France: American discovers healthcare. “A lot of people are kind of making a joke about it,” she says. “Like, welcome to France.” (snip)

Every other country has figured out that it makes far, far more sense (and is far, far more economically sane) for health care to be seen as a public good, but we’re still out here making insurance company CEOs obscenely rich for who knows what reason.

Many American athletes do have access to the United States Olympic and Paralympic Committee’s health insurance policy. But their eligibility for the program is up to their sport’s governing body, and an independent commission appointed by Congress found that “some of the most talented competitors under our flag go to sleep at night under the roof of a car or without sufficient food or adequate health insurance.” More than a quarter of U.S. athletes report earning less than $15,000 per year, and more than 40% said they paid out of pocket for healthcare, with an average cost of $9,200 per person. Only 16% said they’d been reimbursed.

Meanwhile, in 2022, the US Olympic and Paralympic Committee had a net revenue of 61 million dollars and paid their CEO a salary of $1.1 million.

Also meanwhile, NBCUniversal sold $1.2 billion in advertising ahead of the last Olympic Summer Games in Tokyo and say that they have surpassed that number this year (though an exact figure has not been given). (snip)

On the bright-ish side, because of Ramsey’s videos, hundreds of other Olympic athletes have taken advantage of the free healthcare at Olympic Village that they might not otherwise get at home. So that’s nice for them!

AP News: An Israeli airstrike on a Gaza school kills at least 80 people, Palestinian health officials say

https://apnews.com/article/israel-palestinians-hamas-war-10-august-2024-f33867d7596ebb70c1cb3a77fd4437cc

Hi everyone.  Thanks to Ali for correcting my post to include the link.  Ali you really are grand.  The total is not up to 100 dead.  Hugs.  Scottie

Israeli airstrike on a Gaza school used as a shelter kills at least 80, Palestinian officials say

At the link about there are pictures and videos of the devatation and the shock of the people including the kids.  Hugs.  Scottie
 
BY  WAFAA SHURAFA AND SAMY MAGDY
Updated 6:13 PM EDT, August 10, 2024
 

An Israeli airstrike hit a school-turned-shelter in Gaza early Saturday, killing at least 80 people and wounding nearly 50 others, Palestinian health authorities said, in one of the deadliest attacks of the 10-month Israel-Hamas war. A witness said it struck during prayers at a mosque in the building.

It was the latest of what the U.N. human rights office called “systematic attacks on schools” by Israel, with at least 21 since July 4 leaving hundreds dead, including women and children.

“For many, schools are the last resort to find some shelter,” it said after Saturday’s attack.

The Israeli military acknowledged it targeted the Tabeen school in central Gaza City, saying it hit a Hamas command center in a mosque in its compound and killed 19 Hamas and Islamic Jihad fighters. Izzat al-Rishq, a top Hamas official, denied there were militants in the school.

Israel’s military also disputed the toll, saying the “precise munitions” used “cannot cause the amount of damage that is being reported” by the Hamas-run government. It said the steps it took to limit the risk to civilians included the use of a “small warhead,” aerial surveillance and intelligence information.

Walls were blown out on the ground level of the large building. Concrete chunks and twisted metal lay on the blood-soaked floor. Bodies, some in bloodstained shrouds, were placed shoulder to shoulder in makeshift graves, making room for more.

Fadel Naeem, director of the al-Ahli hospital in Gaza City, told The Associated Press that it received 70 bodies along with the body parts of at least 10 others. Gaza’s Health Ministry said that another 47 people were wounded.

“We received some of the most serious injuries we encountered during the war,” he said, with many wounded having limbs amputated and some with severe burns.

The strike hit without warning before sunrise as people prayed, according to witness Abu Anas.

“There were people praying, there were people washing and there were people upstairs sleeping, including children, women and old people,” he said, prayer beads in hand. “The missile fell on them without warning. The first missile, and the second. We recovered them as body parts.”

Three missiles ripped through the two-story building — the first floor housed the mosque, and the second level had a school — where about 6,000 displaced people were taking shelter, said Mahmoud Bassal, a spokesperson for the Civil Defense first responders, who operate under the Hamas-run government.

Many of the casualties were women and children, he said.

A camera operator working for the AP said a missile appeared to have penetrated the floor of the classrooms to the mosque below and exploded.

The U.N. previously said that as of July 6, 477 out of 564 schools in Gaza had been directly hit or damaged in the war, adding that Israel has a duty under international law to provide safe shelter for the displaced.

“There’s no justification for these massacres,” European Union foreign policy chief Josep Borrell said in a statement posted on X, referring to strikes on schools. U.K. Foreign Minister David Lammy said that he was “appalled.” France’s foreign ministry called the recent number of civilian victims in Israeli strikes on schools “intolerable.”

The U.S. said it was deeply concerned about reports of civilians killed.

“Far too many civilians continue to be killed and wounded,” U.S. National Security Council spokesperson Sean Savett said in a statement.

Israel has blamed civilian deaths in Gaza on Hamas, saying the group endangers people by using schools and residential neighborhoods as bases for operations. The U.N. human rights office acknowledged that colocating combatants with civilians is a violation of international humanitarian law, but that Israel must also comply with the law’s principles of precaution and proportionality.

The strike came as U.S., Qatari and Egyptian mediators renewed their push for Israel and Hamas to achieve a cease-fire agreement that could help calm soaring tensions in the region following the assassination of Hamas political leader Ismail Haniyeh in Tehran and a senior Hezbollah commander in Beirut.

Egypt, which borders Gaza, said that the strike on the school showed that Israel had no intention of reaching a cease-fire deal. Neighboring Jordan condemned the attack as a “blatant violation” of international law. Qatar demanded an international investigation, calling it a “heinous crime” against civilians.

Vice President Kamala Harris, speaking to reporters traveling with her in Phoenix, Arizona, on Saturday, said of the Israeli strike in Gaza: “Yet again, far too many civilians have been killed.”

“Israel has a right to go after the terrorists that are Hamas,” she said. “But as I have said many, many times they also have, I believe, an important responsibility to avoid civilian casualties.”

Pressed on the fact that such comments have done little to lower the numbers of civilians in Gaza killed in recent months, Harris said, “First and foremost — and the president and I have been working on this around the clock — we need to get the hostages out.”

“We need a hostage deal and we need a cease-fire,” she said. “And I can’t stress that strongly enough. It needs get to done. The deal needs to get done and it needs to get done now.”

Late on Friday, two separate airstrikes in central Gaza killed at least 13 people, including three children and seven women, hospital authorities said. An AP journalist counted the bodies at the al-Aqsa Martyrs hospital in the central city of Deir al-Balah.

One strike hit a house in the Nuseirat refugee camp, killing seven people, all but one of them women, hospital officials said. Another hit a house in Deir al-Balah, killing six, including a woman and her three children, the hospital said.

Israel’s campaign in Gaza has killed more than 39,790 Palestinians and wounded more than 92,000 others, according to the Health Ministry, which doesn’t distinguish between combatants and civilians in its tally. The war was triggered by Hamas’ Oct. 7 attack in which militants from Gaza stormed into southern Israel, killing around 1,200 people and abducting 250 others.

Families of hostages demonstrated again Saturday night in Tel Aviv seeking a cease-fire deal to bring loved ones home.

More than 1.9 million of Gaza’s prewar population of 2.3 million have been driven from their homes, fleeing repeatedly across the territory to escape offensives. Most are crowded into tent camps in an area of about 50 square kilometers (19 square miles) on the Gaza coast with few basic services or supplies.

In the occupied West Bank, dozens of people gathered in Ramallah to protest the latest Israeli strike on a school.

“The message that must be sent to the world, a numb world, a world that is not moving, is ‘how long will the war continue?’” asked one, Muin Barghouti.

___

Magdy reported from Cairo. Associated Press writer Will Weissert in Washington contributed. 

Harris Campaign: Donald Trump’s Very Good, Very Normal Press Conference

August 8, 2024, 3:56 pm | in

This is quite good:

Donald Trump’s Very Good, Very Normal Press Conference
Split Screen: Joy and Freedom vs. Whatever the Hell That Was (No photo on the page.)
Donald Trump took a break from taking a break to put on some pants and host a p̶r̶e̶s̶s̶ ̶c̶o̶n̶f̶e̶r̶e̶n̶c̶e̶ public meltdown. We have a lot to say about it. Here are some initial thoughts – with more to come.

He hasn’t campaigned all week. He isn’t going to a single swing state this week. But he sure is mad Kamala Harris and Tim Walz are getting big crowds across the battlegrounds.The facts were hard to track and harder to find in Donald Trump’s Mar-a-Lago meltdown this afternoon. He lied. He attacked the media. He made excuses for why he’s off the campaign trail. We’re here to help because his staff clearly isn’t.

But first, an important reminder on the question Donald didn’t answer: how he will vote on the Florida abortion referendum. (He has been ducking this question since April.) We worked to pin down reality so Donald Trump, bless his heart, doesn’t have to. Here are the facts:

We had 12,000 and 15,000 people in Wisconsin and Michigan yesterday, respectively (Not 2,000.)

The ABC debate is September 10th. Not the 25th.

People have spoken to bigger crowds than Donald Trump. (Obama, Clinton, literally anyone at Lollapalooza, Coachella, the World Cup…)

January 6th was decidedly nothing like MLK’s “I Have a Dream” speech. And Trump did not get a bigger crowd than Martin Luther King Jr. on that historic day.

There was famously not a “peaceful transfer” of power after the 2020 election, which Donald Trump fought to overturn. (Famously.) Five police officers died because of January 6th.

Donald Trump said he was off the trail this week because of the Democratic convention. (That convention is not happening this week.)

Trump said they have commercials at a level no one else does. (He is being drastically outspent on the airwaves.)

Governor Josh Shapiro is actually a great guy.

Project 2025 author Tom Homan, the “father” of Trump’s cruel child separation policy, is not a person to praise.

Jewish people should not “have their head examined” for not supporting him. (That’s actually antisemitic.)

Trump said he was not complaining. He in fact very much was.

Trump does not know the difference between asylum seekers and an insane asylum.

Donald Trump does not “cherish” the Constitution.

Abortion is not “less of an issue” for voters. It is not “subdued.” It is not a “small issue” for voters, despite how much Donald Trump wants it to be. Donald Trump did not answer the abortion question “very well in the debate.”

Everybody did not want Roe v. Wade overturned. The American people do not support states banning abortion.

After-birth abortion does not exist.

Minnesota and Virginia are not the same.

Donald Trump doesn’t know what progressive means.

Kamala Harris does not want to take away everyone’s guns. Tim Walz is a gun owner.

Vice President Harris does not support an arms embargo on Israel.

Donald Trump could not remember Tim Walz’s name.

Donald Trump’s tax cuts are not the biggest in history.

We don’t know what “the transgender became such a big thing” is supposed to mean.

Donald Trump will cut Social Security – just like he proposed every year he was in office.

Government was not weaponized against Trump and Steve Bannon.

Mail ballots are secure.

We agree – Elon IS a different kind of guy.

There are no polls that say Donald Trump is going to win in a landslide.

The MAGA base is not 75% of the country.

https://www.insidernj.com/press-release/harris-campaign-donald-trumps-very-good-very-normal-press-conference/

Peace & Justice History 8/9

The subject of South African pass laws makes me think of the GOP’s Agenda 47, and Project 2025…

August 9, 1943

Franz Jägerstätter, an Austrian conscientious objector who reported for induction but refused to serve in the army of the Third Reich, was executed by guillotine at
Brandenburg-Gorden prison. An American, Gordon Zahn, wrote about Jägerstätter while researching the subject of German Roman Catholics’ response to Hitler.
Zahn’s book, In Solitary Witness, influenced Daniel Ellsberg’s decision to stand against the Vietnam War by bringing the previously secret Pentagon Papers to public attention.
Against the Stream by Erna Putz, the story of the courage of Franz Jägerstätter: https://www.c3.hu/~bocs/jager-a.htm

August 9, 1945

The second atomic bomb, “Fatman,” was dropped on the arms-manufacturing and key port city of Nagasaki. The plan to drop a second bomb was to test a different design rather than one of military necessity. The Hiroshima weapon was a gun type, the Nagasaki weapon an implosion type, and the War Department wanted to know which was the more effective design.Responsibility for the timing of the second bombing had been delegated by President Harry Truman before the Hiroshima attack to Colonel Paul W. Tibbets, the commander of the 509th Composite Group on Tinian, one of the Northern Mariana Islands in the western Pacific.

Scheduled for August 11 against Kokura, the raid was moved forward to avoid a five-day period of bad weather forecast to begin on August 10. English translation of leaflet air-dropped over Japan after the first bomb [excerpt]: “We are in possession of the most destructive explosive ever devised by man. A single one of our newly developed atomic bombs is actually the equivalent in explosive power to what 2000 of our giant B-29s can carry on a single mission. This awful fact is one for you to ponder and we solemnly assure you it is grimly accurate.”Of the 195,000 population of the city (many of its children had been evacuated due to bombing in the days just prior), 39,000 died and 25,000 were injured, and 40% of all residences were damaged or destroyed.“What on earth has happened?” said my mother, holding her baby tightly in her arms. “Is it the end of the world?”
Sachiko Yamaguchi (nine years old at the time of the bombing).Hear an eyewitness account of this terrrible event  Photographic exhibit of the aftermath

August 9, 1956


20,000 women demonstrated against the pass laws in Pretoria, South Africa. Pass laws required that Africans carry identity documents with them at all times. These books had to contain stamps providing official proof the person in question had permission to be in a particular town at a given time. Initially, only men were forced to carry these books, but soon the law also compelled women to carry the documents.

August 9, 1966

Two hundred people sat in at the New York City offices of Dow Chemical Company to protest the widespread use in Vietnam of Dow’s flammable defoliant Napalm.
Napalm in use in Vietnam
Read more about Dow Chemical and the use of napalm: https://thevietnamwar.info/napalm-vietnam-war/

August 9, 1987
Hundreds were arrested in an all-day blockade of the Rocky Flats nuclear weapons plant in Golden, Colorado. Protests at Rocky Flats had been going on for some years.

https://www.peacebuttons.info/E-News/peacehistoryaugust.htm#august91943